A meeting of the NI Executive to discuss the possible reintroduction of Covid restrictions is under way.
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Last week, health officials warned that a "significant intervention" could be needed after Christmas.
The vaccination and booster programme have been stepped up in a bid to tackle a rise in cases of the Omicron variant.
The health minister has said the more people that come forward for vaccination, "the less chance there is of severe restrictions".
The highest ever daily number of Covid cases in Northern Ireland - 3,231 - was reported by Department of Health on Wednesday.
Speaking at the opening of the mass vaccination centre at the Titanic Exhibition Centre in Belfast on Tuesday, Robin Swann said up to two thirds of Covid-19 patients in hospital aged under-50 are unvaccinated.
While he would not pre-empt any decisions on restrictions, Mr Swann said there would be "additional asks" made of the public following the executive meeting.
"We have to look at pressures on our health service, on our hospital system, but also the pressures on other key infrastructure as well.
"We'll not boost our way simply out of the Omicron and the threat of what is actually in front of us at this minute in time," he said.
Chief medical officer Sir Michael McBride has previously said that the variant is likely to become the dominant strain in Northern Ireland in January.